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Plavix and renal toxicity

The information contained in the Micromedex products is intended as an educational aid only. The effectiveness of Clopidogrel bisulfate results from its antiplatelet activity, which is dependent on its conversion to an active metabolite by the cytochrome P450 (CYP) system, principally CYP2C19 and so has a reduced effect on platelet activity in patients who are homozygous for nonfunctional alleles of the CYP2C19 gene, (termed “CYP2C19 poor metabolizers”). Overlapping conditions such as acute kidney injury play an important role in the growing epidemiology of CKD, and underlying CKD is in turn an important risk factor for acute kidney injury and end-stage renal disease.

Plavix and renal toxicity

Plavix and renal toxicity

Please see package insert for additional information and possible updates. It measures the potential on your red blood cells by determining how fast they mrate in an electrical field.

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  • Plavix at recommended doses forms less of the active metabolite and so has a reduced effect on platelet activity in patients who are homozygous for nonfunctional alleles of the CYP2C19 gene, (termed "CYP2C19 poor metabolizers").


    Plavix and renal toxicity

    Plavix and renal toxicity

    Plavix and renal toxicity

    Clopidogrel, a thienopyridine derivative, binds specifiy and irreversibly to the platelet P2RY12 purinergic receptor, inhibiting ADP-mediated platelet activation and aggregation [Article:11127873]; [Article:15199474]. All Treatments or procedures are intended to serve as an information resource for physicians or other competent healthcare professionals performing the consultation or evaluation of patients and must be interpreted in view of all attendant circumstances, indications and contraindications.

    Plavix and renal toxicity

    Patients with CKD are at hher risk for major events after percutaneous coronary intervention (PCI) compared with subjects with normal renal function. VIAGRA IN GUATEMALA


    Plavix and renal toxicity:

    Rating: 93 / 100

    Overall: 96 Rates
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